Short Course

Leili Shahriyari, Mathematical Biosciences Institute, The Ohio State University
Stochastic Models for Cell Dynamics in Normal and Tumor Environment

Understanding cell dynamics and the architecture of the stem cell niche and its surrounding neighbors is an important factor in determining the origin of cancer. Moreover, knowledge
of the division patterns of cells, both healthy and malignant, can suggest ways of altering the microenvironment of the tissue to control the cells’ division rate.
Here, we develop several stochastic models for cell dynamics in both normal and cancerous tissues. We investigate the conditions that lead to the development of tumors. Moreover,
we obtain an optimal architecture for a tissue in terms of delaying mutants’ production. We also design a mathematical model for cell dynamics of colon and intestinal crypts. Finally,
we suggest a potential therapy for colon cancer.

Date & Time: 
Tuesday, July 26, 2016, 10:30 - 12:00 & 13:30 - 15:00
Room 221, Dept. Math. Sci., Sharif University of Technology